The influence of externally focused organizational capabilities on the generation of proactive environmental strategies was examined under contingenteffects of uncertainty in the general business environment in 134 North American and European ski resorts. Capabilities of strategic proactivity and continuous innovation were found to be associated with proactive environmental strategies. Managerial perceptions of uncertainty in the general business environment were found to moderate the deployment of the capability of continuous innovation at all levels of uncertainty and stakeholder engagement at low and (...) average levels of uncertainty. The study contributes to the resource-based view by illuminating an important contingency under which these capabilities are likely to be deployed to generate such a strategy. (shrink)

[ES]Una historia de la ontología que pretenda dar cuenta de su acontecer de manera integral y equilibrada, ha de considerar tanto los aspectos historiográficos y filosóficos de sus fuentes así como los relativos a su contexto socio-cultural y necesariamente en relación con los de la metafísica, pues sus historias están indisolublemente ligadas, aunque ello no significa que necesariamente sean las mismas. En este trabajo, se intenta de manera elemental y mínima bosquejar dichas consideraciones, a través de una breve revisión historiográfica (...) de distintas nociones y hechos que puedan configurar una base sólida para la constitución de la historia de la ontología e interpretación de su significado y naturaleza. [EN] A history of ontology that pretends to be an integral and well-balanced account of its development, must considerer the historiographical and philosophical aspects of its sources, as well as the relation with its socio-cultural context, and necessarily, the relation with the same aspects of Metaphysics, as both histories are inextricably related, without necessarily being the same. In this work, it is intended, in a minimal way, to outline such considerations, trough a brief historiographic revision of the distinctive facts and notions that can configure a solid ground for the constitution of the history of ontology and the interpretation of its significance and nature. (shrink)

Una de las aportaciones más importantes de la obra de Ortega se encuentra en su teoría y práctica de la perspectiva. Independientemente de su filiación nietzscheana, el artículo se plantea una posible segunda inspiración en Renan, autor que Ortega conocía bien en el momento de sus primeros trabajos. Para ello, se realiza una comparación de la posición de Renan ante el pensador Lamennais y la de Ortega ante Pío Baroja, donde se aprecian coincidencias no sólo en la interpretación de los (...) personajes, sino en la forma de concebir la práctica intelectual que subyace en sendos trabajos. (shrink)

La relación entre Lukács y la tragedia será uno de los elementos más importantes para poder entender el desarrollo de sus concepciones éticas y estéticas. El papel que juega el personaje principal en el desarrollo de la novela: el héroe, su búsqueda interior, el puesto en el desarrollo histórico de la misma y los demás aspectos relacionados con la refiguración artística. Veremos cómo Lukács emprende esta búsqueda desde la Antigüedad Clásica, pasando por la Edad Media, el Renacimiento, la Ilustración, el (...) Realismo Crítico y su posterior recuperación con el Realismo Socialista. (shrink)

Ionizing radiation is present in various situations in the contemporary world. Defining the quantities and units for this field is a complex scientific task, especially the quantities used in radiological protection (RP) to estimate the damage caused to individuals exposed to radiation (detriment). This article highlights the lack of consensus in the scientific RP community regarding the quantities and units employed in practice from the perspective of the philosophy of science. The basic concepts related to the system of quantities are (...) presented, followed by the problems and criticisms addressed by experts in the field. Several reasons for these problems are identified. The article discusses the scant interest on the part of philosophy of science in RP. The philosophy of science is still dominated by an analytical–conceptual perspective that pays little attention to the actual influence of certain structures better understood when considered from the institutional viewpoint, which is here exemplified by the International Commission on Radiological Protection (ICRP) and the International Atomic Energy Agency (IAEA). (shrink)

Ionizing radiation is present in various situations in the contemporary world. Defining the quantities and units for this field is a complex scientific task, especially the quantities used in radiological protection (RP) to estimate the damage caused to individuals exposed to radiation (detriment). This article highlights the lack of consensus in the scientific RP community regarding the quantities and units employed in practice from the perspective of the philosophy of science. The basic concepts related to the system of quantities are (...) presented, followed by the problems and criticisms addressed by experts in the field. Several reasons for these problems are identified. The article discusses the scant interest on the part of philosophy of science in RP. The philosophy of science is still dominated by an analytical–conceptual perspective that pays little attention to the actual influence of certain structures better understood when considered from the institutional viewpoint, which is here exemplified by the International Commission on Radiological Protection (ICRP) and the International Atomic Energy Agency (IAEA). (shrink)

Vulnerability, understood as a negative aspect of criminalization under immune considerations, constitutes itself as a creative and transformative force that makes it possible to think about a life in common sustained through care and affirmative protection of life. The development of this idea requires three specific stages: in the first, it is described the current democracy as a government technique whose management depends on vulnerable populations; in the second, it is reviewed criminalization as a specific form of immune control; and (...) finally, it is recognized vulnerability as the basis of a new way of democratic life, departing from the attention of certain social groups that have been criminalized due to their precariousness. (shrink)

Resumen En este artículo expongo los aspectos principales del debate suscitado por la aparición del libro de Adolfo Sánchez Vázquez Ciencia y revolución: el marxismo de Althusser. Presentaré primero la crítica del filósofo hispanomexicano a la obra de Louis Althusser y después explicaré la contracrítica del también filósofo Enrique González Rojo que aparece en su libro Epistemología y socialismo. Por último, ofrezco una interpretación de ambos momentos que las concibe como partes de un capítulo significativo de la historia de la (...) filosofía en México.In this article I present the main points of a debate raised by the book Science and Revolution: The Marxism of Althusser by Adolfo Sánchez Vázquez. I begin by addressing the criticism of the Spanish-Mexican philosopher towards the work of Louis Althusser and then I explain the counter-criticism to this approach set forth by -the also philosopher- Enrique González Rojo in his book Epistemology and Socialism. Finally, I offer an interpretation in which both moments in the debate are conceived as a significant chapter in the history of philosophy in Mexico. (shrink)

The natural instinct for members of the Committee on Publication Ethics, which now number almost 12,200, as well as academia, is to assume that this organization works under strict and clearly defined ethical parameters, with a solid vision, and an independent mandate that is not influenced by power, think tanks, or partisan interests. Naturally, whistle-blowing and science shaming are not practices that one would usually associate with an ethics organization like COPE, because they involve ethically and morally questionable practices. Despite (...) this, ethical borders have become blurred between the objectives of Retraction Watch and PubPeer, two self-moderated science watchdogs that rely heavily on these questionable practices, in their efforts to grow and survive, and the values espoused by COPE. A Retraction Watch post, in which the former COPE Chair, Virginia Barbour, made a claim of apparent harassment, is the most striking example of the dangers when collaboration may take place between science-shaming websites, and an ethics organization, COPE. These bonds appear to have been in development for a number of years already, with the inclusion of Elizabeth Wager, the former COPE Chair, as a director of The Center for Science Integrity Inc., Retraction Watch’s parent organization. Retraction Watch was financed by, among other groups, the Laura and John Arnold Foundation, whose leader, John Arnold, an ex-Enron trader, declared a “war on bad science”, which may naturally include the destruction of aspects of science as well. Retraction Watch embraces several infamous pseudonymous personas under the broad umbrella of freedom of speech, liaising thereby with PubPeer. There is no doubt that errors in the literature need correcting, but this apparent connection with COPE raises questions about the basic ethical foundation of this relationship. Are scientists to embrace this bond between COPE and science watchdogs and pseudonymous whistle-blowers as the new normal in the correction of the scientific literature? This opinion piece puts forward arguments why the author believes that the ethical compass of COPE has become skewed. (shrink)

Este artículo se inscribe en el debate sobre las «luchas por el reconocimiento de la diferencia» (Fraser, 2008) que ha ido creciendo y desarrollándose en los últimos años. Se enfoca concretamente en el denominado Movimiento Loco como territorio de confluencias para las reivindicaciones de personas y colectivos que han vivido la experiencia de la psiquiatrización en el ámbito de la salud mental. El texto plantea una serie de variables analíticas y conceptos que permiten una aproximación a este Movimiento en España (...) como un espacio político de construcción en común para producir testimonio y conocimiento que habiliten otras posibilidades de comprensión de la experiencia social del sufrimiento psíquico. Propone un itinerario que permite observar el fenómeno como un territorio de disputa, diálogo y escucha social que deriva en la promoción de una conciencia crítica; como un intento de emancipación, como una instancia en donde las personas renuncian a ser objetos de intervención de los saberes expertos para devenir sujetos en sus propios proyectos vitales. A partir de la incorporación del concepto de «Injusticia Epistémica» de Miranda Fricker y de la teoría del etiquetado entre otras referencias, el artículo entiende las violencias vividas por las personas psiquiatrizadas como punto de partida para el origen del Movimiento. Al mismo tiempo, reflexiona sobre las dificultades que genera la noción de locura como eje de identificación en la articulación de las acciones. No se plantea una definición cerrada de lo que significa ser loco sino que se entiende como una categoría que se construye a partir de articularse como sujeto de derecho frente a un otro experto que históricamente ha clausurado esa posibilidad. (shrink)

This essay attempts to clarify the position of Nāgārjuna in the history of Buddhist philosophy by comparing the concept of emptiness in the Pāli Nikāyas and the Mūlamadhyamakakārikā. It is argued that the identity of samsāra with nirvāna, the emptiness of svabhāva of all dharmas, and the equating of emptiness and dependent arising are not revolutionary innovations of Nāgārjuna or the second turning of the wheel of Dharma, but orthodox philosophical moves entailed by the teachings of early Buddhism.

In the Tractatus Logico-Philosophicus the identity signal is excluded from any meaningful language use, because expressions such as “a = a” and “a = b” cannot be elementary and necessary propositions at the same time. Hence, the identity is used as a operation. That use does not intended to be be meaningful, but only to indicate the intersubstitutable nature of the signs involved.

La Société qui vient [The Society to Come], a book edited by Princeton professor and current holder of the Chair of Public Health at the Collège de France, Didier Fassin, cannot be accused of sinning by modesty. This is a collective work of more than 1300 pages, grouped in seven parts and comprising no fewer than 64 chapters. Each chapter is devoted to a fundamental question of our present time and is written by an author who is an expert in (...) her or his domain or field of research. Each of the first six parts deals with a set of broad themes of general interest: ‘challenges ( enjeux), policies, worlds, inequalities, recognition and exploitation’. A seventh, final, and non-thematic part is free of a prior theme and is composed of non-French authors. (shrink)

Philosophie des expérientes radicales, livro recém-publicado pelo filósofo pragmatista e professor da Universidade de Lyon III, Stéphane Madelrieux, propõe uma maneira original e inovadora de ler a filosofia francesa do século XX. Sem abordá-la por caminhos tradicionais, tais como a sucessão cronológica de gerações (1860, 1900, 1900, etc), conceitos típicos (espírito e vida; existência e transcendência; dialética e práxis; estrutura e descontinuidade; diferença e desconstrução, etc.), correntes hegemônicas (espiritualismo bergsoniano, filosofias da vida; existencialismos; hegelianismos, marxismos; estruturalismo, epistemologia histórica; pós-estruturalismo ou (...) pós-modernismo, etc.), Madelrieux elege seis autores franceses (Henri Bergson, Jean Wahl, Gilles Deleuze, Georges Bataille, Maurice Blanchot e Michel Foucault), todos do século XX, para, em seguida, analisá-los pelo prisma do "empirismo metafísico". O que interessa a Madelrieux é apontar a presença de um programa inédito, não trabalhado na literatura filosófica, que amarra experiência e metafísica, e que explica uma parte importante da filosofia do século XX, notadamente na França. (shrink)

Este artículo revisa el modo en que la aparición de objetos críticos, como el Portabotellas de Duchamp, hacen entrar en crisis las nociones tradicionalmente aceptadas respecto de la obra de arte: su manualidad (la “buena factura”, producto de la destreza o habilidad del artista), su función representativa (mímesis) y su valor estético (el ser “bello”, objeto de una contemplación pura y desinteresada). Se plantea, así, que la aparición del ready made configura el momento final de un proceso de disolución de (...) las convenciones artísticas (tanto respecto de la producción como de la valoración de las obras de arte) imperantes hasta el momento. Teniendo en cuenta todo esto, la pregunta que se intenta responder, al final, es: ¿cómo es posible que algo como el Portabotellas pudiera haber sido aceptado como arte, si no cumplía con las condiciones básicas de la noción tal y como se la aceptaba entonces? (shrink)

En este Editorial se presenta una reflexión sobre la gestión de la revista en Redalyc, para luego presentar los artículos de la sección de filosofía y de teología.

Hacer un recorrido por las influencias que recibió la obra de Georg Lukács de los dramaturgos Ibsen, Strindberg y Shakespeare. Ver que los inicios de su rechazo hacia la burguesía, los primeros conatos de aspectos revolucionarios y la posterior inclinación hacia la estética vienen marcados desde esta temprana influencia que ejercieron sobre él los dramaturgos antes nombrados. Destacar de manera clara los giros dados por Lukács a lo largo de su vida intelectual. La cual desde luego estuvo marcada por la (...) influencia en las respectivas épocas por autores diferentes. hacer énfasis en los aspectos más destacados de la influencia recibida: la teoría del reflejo, la periodicidad, el dinero, la singularidad privada, la soledad, la relación del público con el drama etc. (shrink)

En el marco del juego hipotético del diálogo El Parménides, donde se examinan las posibilidades de lo Uno y lo Múltiple en relación con su participación en el ser, surge, como condición de dicha participación en tiempos diferentes, la existencia del instante. Este elemento irrumpe fraccionando la continuidad de la magnitud del movimiento, introduciendo así el "cambio" como el concepto que permite eludir la contradicción en que podría caer el Uno al participar y no participar simultáneamente. Se exponen, de este (...) modo, las circunstancias de la aparición tematizada del instante en el diálogo, y su rasgo intemporal como característica sobresaliente. (shrink)

In this study a combination of computer tools for coupling and virtual screening is detailed, in 108 active molecules and 3620 decoys to find stabilizers for G quadruplex. To have more precise results, combinations of coupling programs with fifteen energy scoring functions were applied. The validation and evaluation of the metrics was done with the CompScore genetic algorithm. The results showed an increase in BEDROC and EF of 50% compared to other strategies, as well as reflecting early recognition of active (...) molecules. From these results it is possible to work with the molecules that showed a good early recognition and evaluate their effect as G4 stabilizers. This ensures more efficient and accurate results in the preclinical stage for the development of anticancer drugs. Keywords: Enrichment metrics; telomere; G quadruplex ; CompScore. References [1]M. Porru, P. Zizza, M. Franceschin, C. Leonetti and A. Biroccio. «EMICORON: A multi-targeting G4 ligand with a promising preclinical profile» 2017. Biochimica et Biophysica Acta - General Subjects, 1861, 1362–1370. [Online]. Available: https://doi.org/10.1007/s00294-018-0836-6. [2]K. Tomita. «How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis». Current Genetics, 64, 1177–1181. 2018. [Online]. Available: https://doi.org/10.1016/j.bbagen. 2016.11.010. [3]M. Jafri, S. Ansari, M. Alqahtani and J. Shay. «Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine., 2016. [Online]. Available: https://doi.org/10.3390/ijms19020482. [4]J. Huppert and S. Balasubramanian. «G-quadruplexes in promoters throughout the human genome». 35, 406–413. 2007. [Online]. Available: https://doi.org/10.1016/j.bbapap.2017.06.012. [5]S. Joy, Vijayakumar, S. Choi and H. Sunhye. «Role of computer-aided drug design in modern drug discovery». Archives of Pharmacal Research. 2015. [Online]. Available: https://doi.org/10.1007/s12272-015-0640-5. [6]S. Asamitsu, S. Obata, Z. Yu, T. Bando and H. Sugiyama. «Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy». Molecules, 24, 429. 2019. [En línea]. Available: https://doi.org/10.3390/molecules24030429. [7]R. Monsen and J. Trent. «Biochimie G-quadruplex virtual drug screening : A review». Biochimie, 152, 134–148. 2018. [Online]. Available: https://doi.org/10.1039/c9cc06748e. [8]J. Beauvarlet, P. Bensadoun, E. Darbo, G. Labrunie, E. Richard, I. Draskovic and M. Djavaheri-mergny. «Modulation of the ATM / autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells». 1–18. 2019. [Online]. Available: https://doi.org/10.1093/nar/gkz095. [9].Z. Crees, J. Girard, Z. Rios, G. Botting, K. Harrington and C. Shearrow. « Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy».2014. [Online]. Available: https://doi.org/10.2174/1381612820666140630100702. [10].M. Meier, A. Moya-torres, N. Krahn, M. Mcdougall, L. Orriss, E. Mcrae and T. Patel. «Structure and hydrodynamics of a DNA Gquadruplex with a cytosine bulge»., 1–13. 2018. [Online]. Available: https://doi.org/10.1093/nar/gky307. (shrink)

There is a global shortage of nurses, leading many countries to recruit internationally qualified nurses (IQNs) to fill the gap. However, IQNs encounter challenges in integrating into their new professional environment, particularly in their interactions with locally qualified nurses (LQNs). Intraprofessional cultural competence (IPCC), defined as ‘a set of congruent behaviours and attitudes that enable professionals to work respectfully and effectively in cross‐cultural situations’, may be a strategy to address these challenges. Content analysis was used to examine nursing regulatory documents (...) (Standards for Practice [Standards] and Codes of Conduct [Codes]) from the United Kingdom, New Zealand and Australia. Data were extracted and organised based on four key themes relevant to IPCC. The analysis revealed a focus on ‘Mutual collaboration and professional relationships’ in six regulatory documents, with explicit commitments to preventing racism and discrimination in the Australian and NZ Codes. However, issues such as racism, discrimination, bullying and harassment faced by IQNs are not comprehensively addressed, as the documents mainly prioritize culturally appropriate patient interactions over relationships between colleagues. Using regulatory documents to address IPCC may influence positive change such as improving communication, and preventing racism, bullying, discrimination and harassment within nursing. (shrink)